ABSTRACT
Background: Diseases primarily inflicting prostate gland areinflammation, benign prostatic hyperplasia and cancer.Prostate specific antigen is a glycoprotein and is expressed byboth normal and neoplastic prostate tissue. It has been widelyused in the diagnosis and management of patients withprostatic cancer. Studies from various research workersdiscuss the proportion of prostatic disorder among Indianstates like Delhi, Mumbai, Bangalore, Chennai, Gujrat etc butthere is paucity of data from the rural areas. The present studywas conducted to find out the patterns of prevalence ofprostatic lesions among people of Rohtas district of Bihar andto correlate histology with respect to serum PSA levels inbiopsy specimens of men with prostatic disease.Materials and Methods: The study included 153 prostatictissue specimens (both transurethral resection of the prostateand prostatic biopsies) received in the Department ofPathology, over the period of 2-year from October 2017 toSeptember 2019. Relevant clinical data and serum PSA valuewas recorded, and Gleason’s microscopic grading was used tograde malignant lesions. Statistical analysis was performed inMicrosoft office excel 2007.Results: Mean age of presentation was 63 ± 10.56 years withmaximum incidence in the seventh decade of life. Onhistopathological examination, 52.9% had benign prostatichyperplasia, 35.9% had BPH with chronic prostatitis and 8.5%had adenocarcinoma. Other lesions encountered were highgrade prostate intraepithelial neoplasia (3 cases), sarcomatoidcarcinoma (1 case). Inflammatory pathology (55/153) wascommon at all PSA levels. Patients with PSA >20 ng/ml werewere more likely to show cancer. There exists a positivecorrelation between the increasing PSA levels and chances ofadenocarcinoma, the findings were statistically significant.Conclusion: Our study suggests that most frequentlyencountered prostatic lesion was BHP, commonly seen in theage group of 51-60 year The malignant lesions were commonamong the males of more than 60 years. Strong correlation ofprostate specific antigen levels of > 20.1 ng/ml with carcinomaprostate was seen.